回答編集履歴
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追記。普通のやりかた（？）
test
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@@ -47,3 +47,43 @@
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回答頂いた方ありがとうございました。
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追記です。こちらの方が普通のやりかたかも知れません。
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```python
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>>> t4 = pd.concat([t2, t3],axis=1,join='inner',keys=['x','y'])
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>>> t4
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x y
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TIME TIME
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USER DATE
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1 2016-02-01 2016-02-01 09:25 2016-02-01 18:01
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2 2016-02-01 2016-02-01 09:59 2016-02-01 21:55
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>>> t4['DELTA'] = pd.to_datetime(t4[('y','TIME')])-pd.to_datetime(t4[('x','TIME')])
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>>> t4
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x y DELTA
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TIME TIME
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USER DATE
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1 2016-02-01 2016-02-01 09:25 2016-02-01 18:01 08:36:00
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2 2016-02-01 2016-02-01 09:59 2016-02-01 21:55 11:56:00
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```
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